Jaume Padilla, PhD
Dr. Padilla's overall research focuses on understanding the physiological and molecular links between physical inactivity, metabolic disease and vascular complications. A primary area of interest is studying the mechanisms by which insulin-stimulated skeletal muscle blood flow is impaired with sedentarism, obesity and type 2 diabetes. A detailed understanding of the precipitating factors and mechanisms underlying the defects in vascular insulin signaling is critical for the development of therapeutic strategies aimed at improving glycemic control and protecting against cardiovascular disease. Another particular area of interest is studying the mechanisms by which hemodynamic forces (e.g., shear stress) modulate endothelial cell function and the susceptibility for vascular disease. Furthermore, we are investigating the role of obesity-associated adipose tissue dysfunction in mediating metabolic and vascular derangements. Dr. Padilla’s research, funded by NIH, is integrative and incorporates in vitro cell and tissue culture models, in vivo studies in small and large animals, and experiments in humans.
- Article Impact Award, American Journal of Physiology-Heart and Circulatory Physiology, 2017
- American Physiological Society Career Enhancement Award, 2017.
- New Investigator Award, American Physiological Society Cardiovascular Section, 2016.
- Experimental Physiology Annual Inaugural Review Award, 2015.
- New Investigator Award, American Physiological Society Environmental and Exercise Physiology Section, 2015.