Dr. Padilla’s research program focuses on understanding the mechanisms linking metabolic and cardiovascular disease. A primary focus is the study of mechanisms causing endothelial insulin resistance and vascular dysfunction associated with physical inactivity, obesity, and type 2 diabetes. A detailed understanding of the precipitating factors and mechanisms underlying the defects in vascular insulin actions is critical for the development of therapeutic strategies aimed at improving glycemic control and cardiovascular outcomes. Emphasis is also placed on investigating the role of adipose tissue inflammation and dysfunction in mediating such vasculometabolic derangements. Dr. Padilla’s research, funded by NIH, is integrative and incorporates biochemical and molecular techniques, in vitro cell and tissue culture models (e.g., study of isolated arteries using pressure- and wire-myography), in vivo studies in genetic mouse models and large animals, as well as clinical studies in human subjects using non-invasive vascular imaging modalities including Doppler and contrast-enhanced ultrasound under a myriad of experimental conditions.